STUDIES ON HERPES SIMPLEX VIRUS I

Studies on herpes simplex virus. I. The stability and preservation of egg-adapted herpes simplex virus.

In animal tissues the virus of herpes simplex is very stable and can be preserved at refrigerator temperature or in the frozen state for many months. Egg-adapted herpes virus, on the other hand, is said to be relatively unstable so that it cannot be satisfactorily preserved and stored (Scott, 1948a,b). Two recent standard texts on viruses state that "egg virus appears harder to keep, very littl...

Herpes Simplex Virus and Langerhans Cell Histiocytosis

Background and objective: Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferative disorder of unknown etiology and mainly affects young children. The histological feature is granuloma-like proliferation of langerhans-type dendritic cells. Although the possible role of viruses such as Epstein-Barr virus (EBV, Human Herpes virus -4</...

The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus

Herpes simplex virus (HSV) stimulates DNA synthesis in mouse spleen cultures prepared from normal, macrophage-depleted, and T-cell-depleted spleen cells, but not from thymocytes. In addition, a polyclonal antibody response is observed in HSV-infected spleen cultures. These findings indicate that the cells stimulated to undergo DNA synthesis after HSV infection appear to be the bone marrow-deriv...

Tzanck smears in herpes simplex virus infections

Background: The diagnosis of herpes simplex virus may requirevirological confirmation. Tzanck smear is an old, rapid, costeffective but nonspecific method that has been recently re-evaluatedas a method for the diagnosis of herpes virus infection. This studywas conducted to compare Tzanck smear and viral culture in thediagnosis of herpes simplex virus infection in patients clinicallysuspected to...

Serodiagnosis of Herpes Simplex Virus-I Infections by a Prepared Antigen